The problem with the Second Amendment goes beyond it being ineffective against a tyrannical government; it is actually harmful to everyday citizens. With hundreds of millions of guns around, you’re simply more likely to catch a bullet, and this is only going to get worse. Much, much worse.
Beyond even this, given that the main driver of preserving the overtly outmoded Second Amendment is the capitalistic interests of the military industrial complex, the ultimate irony is that the Second Amendment is actually counterproductive at resisting tyranny — it is filling the coffers of tyranny. The very same entities selling us weapons are developing spy satellites, drones, and other means of eroding our anonymity, connection, and encryption.